ΕΡΕΥΝΗΤΙΚΗ ΟΜΑΔΑ 5
Τίτλος: «Μελέτη Βιοδραστικών Φυσικών Ενώσεων με Φαρμακολογικό Ενδιαφέρον σε Παθοφυσιολογικές Καταστάσεις που Συνδέονται με Αγγειογένεση και Φλεγμονή»
Υπεύθυνος: Λουτράρη Ελένη, Μοριακή Βιολόγος PhD
Άμεσοι Επιστημονικοί Συνεργάτες:
Μιχαηλίδου Μαίρη, MSc, PhD, μεταδιδακτορική ερευνήτρια
Ιωάννα Νάκα, προπτυχιακή φοιτήτρια Σχολής Χημικών Μηχανικών ΕΜΠ σε διπλωματική ερευνητική εργασία
ARTICLES:
(citations: 281, source: Scopus ISI)
Scopus link:
- 1. Michailidou, M., Melas, I., Messinis, D., Klamt, S., Alexopoulos, L., Kolisis, F.N. and Loutrari, H. Analysis of inflammatory and phosphoproteomic response networks to identify natural inhibitors of human hepatocellular carcinomas. Submitted in Hepatology.
- 2. Loutrari, Η., Magkouta, S., Papapetropoulos, A. and Roussos, C. (2011) Mastic Oil Inhibits the Metastatic Phenotype of Mouse Lung Adenocarcinoma Cells. Cancers, 3, 789-801
- 3. Theodossiou, E., Loutrari, H., Stamatis, H. Roussos C, Kolisis FN. (2011), Biocatalytic synthesis and antitumor activities of novel silybin-acylated derivatives with dicatboxylic acids. N Biotechnol. 28(4):342-8
- 4. Morbidelli, L., Pyriochou, A., Filippi, S., Vassiliades, Y., Roussos, C., Loutrari, H., Giannis, A., Stössel, A., Ziche, M. and Papapetropoulos, A. (2010). The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability. Am J Physiol Regul Integr Comp Physiol., 298(3):R824-32.
- 5. Moulos, P. Papadodima, O., Chatziioannou, A., Loutrari, H., Roussos C and Kolisis, F.N. (2009). A transcriptomic computational analysis of mastic oil-treated Lewis lung carcinomas reveals molecular mechanisms targeting tumor cell growth and survival BMC Med Genomics, 2:68.
- 6. Magkouta, S., Stathopoulos, G.T., Psallidas, I., Papapetropoulos, A., Kolisis, F.N., Roussos, C. and Loutrari, H. (2009). Protective effects of mastic oil from Pistacia lentiscus variation chia against experimental growth of Lewis Lung Carcinoma. Nutrition & Cancer, 61(5): 640-648
- 7. Theodossiou, E., Katsoura, M.H., Loutrari, H., Purchartova , K., Kren, V., Kolisis, F.N. and Stamatis, H. (2009). Enzymatic preparation of acylated derivatives of silybin in organic and ionic liquids media and evaluation of their anti-tumor proliferative activity. Biocatalysis and Biotransformations, 27: 161 – 169
- 8. Xanthakis, E., Magkouta, S., Loutrari, H., Stamatis, H., Roussos, C. and Kolisis, F.N. (2009). Enzymatic synthesis of perillyl alcohol derivatives and investigation of their antiproliferative activity. Biocatalysis and Biotransformation, 27: 170– 178.
- 9. Xanthakis, E., Theodossiou, E., Stamatis, H., Magkouta, S., Loutrari, H., Roussos, C. and Kolisis, F.N. (2009). Biotransformations of natural compounds: Structural and functional diversity of novel derivatives. Pure and Applied Chemistry, 82:1-16
10. Stathopoulos, G.T., Moschos, C., Loutrari, H., Kollintza, A., Psallidas, I., Karabela, S., Magkouta, S., Zhou, Z., Papiris, S.A., Roussos, C. and Kalomenidis, I. (2008). Zoledronic acid is effective against experimental malignant pleural effusion. American Journal of Respiratory and Critical Care Medicine, 178:50-59
11. Loutrari, Η., Magkouta, S., Pyriochou, A., Koika, V., Kolisis, F.N., Papapetropoulos, A. and Roussos, C. (2006). Mastic oil from Pistacia lentiscus var. chia inhibits growth and survival of human K562 leukemia cells and attenuates angiogenesis. Nutrition & Cancer. 55:86-93.
12. Mellou, F., Loutrari, H., Stamatis, H., Roussos, C. and Kolisis F.N. (2006). Enzymatic esterification of flavonoids with unsaturated fatty acids: Effect of the novel esters on Vascular Endothelial Growth Factor release from K562 cells. Process Biochemistry.41:2029-2034
13. Kotanidou A., Loutrari H., Papadomichelakis E., Glynos K., Magkou C., Armaganidis A., Papapetropoulos A., Roussos C. and Orfanos S.E. (2006). Inhaled activated protein C attenuates lung injury induced by endotoxin in mice. Vascular Pharmacology, 45: 134-140
14. Loutrari, H., Hatziapostolou, M., Skouridou, V., Papadimitriou, E., Roussos, C., Kolisis, F.N. and Papapetropoulos, A. (2004) Perillyl alcohol is an angiogenesis inhibitor. J Pharmacol Exp Ther. 311:568-75.
15. Franqueville, Ε., Loutrari, H., Mellou, F., Stamatis, H., Friboulet, A. and Kolisis F.N. (2003). Reverse micelles, a system for antibody-catalysed reactions. J. Mol. Catalysis B: Enzymatic, 21: 15-17.
16. Franqueville, Ε., Stamatis, H., Loutrari, H, Friboulet, A. and Kolisis F.N. (2002). Studies on the catalytic behaviour of a cholinesterase-like abzyme in an AOT microemulsion system. J. Biotechnology, 97: 177-182.
17. Loutrari, H., Kokla, A., Trakas, N. and Tzartos, S.J. (1997). Expression of human-Torpedo hybrid acetylcholine receptor (AChR) for analyzing the subunit specificity of antibodies in sera from patients with myasthenia gravis (MG). Clin. Exp. Immunol., 109: 538-546.
18. Vretou, E., Loutrari, H., Mariani,L., Costelidou, K., Eliades, P., Conidou, G., Karamanou S., Mangana, O. , Siarkou, V ., Papadopoulos, O., (1996) Diversity among abortion strains of Chlamydia psittaci demonstrated by inclusion morphology, polypeptide profiles and monoclonal antibodies. Veterinary Microbiology 51: 275-289.
19. Loutrari, H., Kokla, A. and Tzartos, S.J. (1992). Passive transfer of experimental myasthenia gravis via antigenic modulation of acetylcholine receptor. Eur. J. Immunol, 22: 2449-2452.
20. Loutrari, H., Tzartos, S.J. and Claudio, T. (1992). Use of Torpedo‑mouse hybrid acetylcholine receptors reveals immunodominance of the a‑subunit in myasthenia gravis antisera. Eur. J. Immunol., 22: 2949-2956.
21. Tzartos, S.J., Cung, M.T., Demange, P., Loutrari, H., Mamalaki, A., Marraud, M., Papadouli, I., Sakarellos, C., and Tsikaris, V. (1992). The main immunogenic region (MIR) of the nicotinic acetylcholine receptor and the anti‑MIR antibodies. Mol. Neurobiology, 5: 1-29.
22. Tzartos, S.J., Barkas, T., Cung, M.T., Kordossi, A., Loutrari, H., Marraud, M., Papadouli, I., Sakarellos, C., Sophianos, D. and Tsikaris, V. (1991). The main immunogenic region of the acetylcholine receptor. Structure and role in myasthenia gravis. Autoimmunity, 8: 259‑270.
23. Tzartos, S.J., Loutrari, H.V., Tang, F., Kokla, A., Walgrave, S.L., Milious, R. and Conti‑Tronconi, B.M., (1990). Main immunogenic region of Torpedo electroplax and human muscle acetylcholine receptor: Localization and micro‑heterogeneity revealed by the use of synthetic peptides. J. Neurochem., 54: 51‑61.
Articles to be published
Papadodima, O., Loutrari, H., Kolisis, F.N. and Chatziioannou, A. Global gene expression profiling and computational investigation indicates modulation of major common pathways in mastic oil-treated human K562 lymphoblastomas, A549 lung and HCT116 colon carcinomas. Manuscript in preparation