Tropopoiitiko Fek">TEXAN SA


Τίτλος: «Κυτταρική Σηματοδότηση και Φαρμακολογία»

Υπεύθυνος: Ανδρέας Παπαπετρόπουλος


Selected Publications

 A. Kotanidou, A. Xagorari, E. Bagli, P. Kitsanta, T. Fotsis, A. Papapetropoulos,  Ch. Roussos. Luteolin reduces lipopolysaccharide-induced lethal toxicity and expression of proinflammatory molecules in mice. Am J Respir Crit Care Med 165:818-823, 2002


I. Kosmidou, T. Vassilakopoulos, A. Xagorari, S. Zakynthinos, A. Papapetropoulos, Ch. Roussos. Production of interleukin –6 by skeletal myotubes:role of reactive oxygen species Am. J. Resp. Cell Mol. Biol.. 26:587-593, 2002


Z. Zhou, S. Gross, C. Roussos, S Meurer, W. Müller-Esterl and A. Papapetropoulos. Structural and functional characterization of the dimerization region of soluble guanylyl cyclase. J. Biol. Chem. 279:24935-24943, 2004


Papapetropoulos A, Zhou Z, Gerassimou C, Yetik G, Venema RC, Roussos C, Sessa WC, and Catravas JD. Interaction between hsp90 and soluble guanylyl cyclase: physiological significance and mapping of the domains mediating binding. Mol Pharmacol. 68:1133-41, 2005.


 Papapetropoulos A, Simoes DC, Xanthou G, Roussos C, and Gratziou C. Soluble guanylyl cyclase expression is reduced in allergic asthma. Am J Physiol Lung Cell Mol Physiol. 290:L179-84, 2006 


S. E. Orfanos, A. Kotanidou, C. Glynos, C. Athanasiou, S. Tsigkos, I. Dimopoulou, C. Sotiropoulou, S. Zakynthinos, A. Armaganidis, A. Papapetropoulos, Ch. Roussos. Angiopoietin-2 is increased in severe sepsis: correlation with inflammatory mediators. Crit. Care Med. 35:199-206, 2007


C. Glynos, A. Kotanidou, S.E. Orfanos, Z. Zhou, D.C. Simoes, C. Magkou, Ch. Roussos, A. Papapetropoulos, Soluble Guanylyl Cyclase Expression is Reduced in LPS-induced Lung Injury. Am J Physiol Regul Integr Comp Physiol. 292: R1448-55, 2007.


D.C. Simoes, T. Vassilakopoulos, D. Toumpanakis, K. Petrochilou, C. Roussos, A. Papapetropoulos. Angiopoietin-1 Protects Against Airway Inflammation and Hyperreactivity in Asthma. Am J Respir Crit Care Med. 177:1314-21, 2008 


A. Papapetropoulos, Pyriochou A, Altaany Z, Yang G, Marazioti A, Zhou Z, Jeschked MG, Branskid L.K., Herndon D.N., Wang R. and Szabo C. Hydrogen sulfide is an endogenous stimulator of angiogenesis. Proc Natl. Acad Sci USA 106:21972-7, 2009


M. Bucci¸ A. Papapetropoulos , V. Vellecco, Z. Zhou, A. Pyriochou, C. Roussos, F. Roviezzo, V. Brancaleone, G. Cirino. Hydrogen Sulfide Is an Endogenous Inhibitor of Phosphodiesterase Activity Arterioscler Thromb Vasc Biol. 30:1998-2004, 2010


C. Coletta, A. Papapetropoulos, K. Erdelyi, G. Olah, K. Modis, P. Panopoulos, D. Gero, C. Szabo. Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of vascular function. Proc Natl Acad Sci USA 109:9161-6, 2012.


M. Bucci, A. Papapetropoulos, V. Vellecco, Z. Zhou, A. Zaid, P. Giannogonas, A. Cantalupo, S. Dhayade, K. P. Karalis, R. Wang, R. Feil, G. Cirino. cGMP-dependent protein kinase contributes to hydrogen sulfidestimulated vasorelaxation. PLOS One 7:e53319. doi: 10.1371/journal.pone.0053319, 2012


A. Asimakopoulou, P. Panopoulos, C. T. Chasapis, C. Coletta, Z. Zhou, G. Cirino, A. Giannis, C. Szabo, G. A. Spyroulias, A. Papapetropoulos. Selectivity of commonly used pharmacological inhibitors for cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE). Br. J. Pharmacol.  169: 922–932, 2013.


C. Glynos, L. L. Dupont, T. Vassilakopoulos, A. Papapetropoulos, P. Brouckaert, A. Giannis, G. F. Joos, K. R. Bracke, G. G. Brusselle.The role of soluble guanylyl cyclase in Chronic Obstructive Pulmonary Disease. Am. J. Respir Crit. Care Med. In press



Team members

Zongmin Zhou, Ph.D. 2001-present

Nasa Chatzianastasiou, MSc, 1998-present

Kostantinos Glynos MD, PhD, 2012-present

Antonia Asimakopoulou, MSc, 2012-present

Thani Pavlidou, MSc, 2013-present

Sofia-Iris Bibli, MSc, 2013-present


Past team members

Ioanna Kosmidou, MD, 1998-2002

Xagorari Aggeliki, Ph.D. 1999-2001

Roula Andreopoulos, Ph.D. 1999-2000

Stelios Tsigkos, MD, 2001-2007

Christina Gerassimou, M.Sc., 2002-2007

Davina Simoes, Ph.D. 2003-2009

George Haramis, MD, 2006-2008



 Figure 1



Figure 2


Figure 1: (A) Omit electron density maps for 20 (red sticks) bound to heme binding pocket of C139A H-NOX (gray sticks, interacting amino acids are labeled) (2Fo-Fc omit density in blue at 0.9σ and FoFc omit density in green @ 3.0σ). (B) 2Fo-Fc map (blue color at 1.0σ) for 20 (in red color) showing no well defined density for the terminal benzyl ring. For comparison, BAY 58-2667 is shown in yellow and the residues are labeled.

Figure 2: (A) Superposition of 20 bound C139A structure and BAY 58-2667 bound Ns H-NOX structure, 20 is shown in red spheres and BAY 58-2667 is shown in yellow spheres. C139A:20 protein is shown in gray cartoon and sticks while Ns H-NOX:BAY 58-2667 protein is shown in yellow cartoon and sticks. This picture clearly shows that the αF helix in both structures does not alter its position whereas its C-terminus residues (110-114) have changed significantly. (B) 20 is shown in red sticks and BAY 58-2667 is shown in yellow sticks. C139A protein is shown in gray sticks and Ns H-NOX is shown in yellow sticks. 2Fo-Fc map is shown in blue at 1σ. The terminal benzyl ring of 20 when bound to Ns H-NOX clearly forces the phenyl ring of F112 away from the loop. (C) Distances between the atoms of the superposed loop region comprising of 111-113 residues.