Tropopoiitiko Fek

ΕΡΕΥΝΗΤΙΚΗ ΟΜΑΔΑ 5

Τίτλος: «Μελέτη Βιοδραστικών Φυσικών Ενώσεων με Φαρμακολογικό Ενδιαφέρον σε Παθοφυσιολογικές Καταστάσεις που Συνδέονται με Αγγειογένεση και Φλεγμονή»

Υπεύθυνος: Λουτράρη Ελένη, Μοριακή Βιολόγος PhD 

Άμεσοι Επιστημονικοί Συνεργάτες:

Μιχαηλίδου Μαίρη, MSc, PhD, μεταδιδακτορική ερευνήτρια

Ιωάννα Νάκα, προπτυχιακή φοιτήτρια Σχολής Χημικών Μηχανικών ΕΜΠ σε διπλωματική ερευνητική εργασία

 

ARTICLES:

 (citations: 281, source: Scopus ISI)

 Scopus link:

 http://www.scopus.com/results/results.url?sort=plf-f&src=s&st1=loutrari&st2=h&nlo=1&nlr=20&nls=&sid=D21627138410B7E8C1FFA78B50AF5C89.aXczxbyuHHiXgaIW6Ho7g%3a452&sot=anl&sdt=aut&sl=81&s=AU-ID%28%22Loutrari%2c+Heleni%22+35262726400%29++OR+AU-ID%28%22Loutrari%2c+Heleni+V.%22+6602972446%29&cl=t&offset=1&origin=resultslist&ss=plf-f&ws=r-f&ps=r-f&cs=r-f&cc=10&txGid=D21627138410B7E8C1FFA78B50AF5C89.aXczxbyuHHiXgaIW6Ho7g%3a70#

 

  1. 1.  Michailidou, M., Melas, I., Messinis, D., Klamt, S., Alexopoulos, L., Kolisis, F.N. and Loutrari, H. Analysis of inflammatory and phosphoproteomic response networks to identify natural inhibitors of human hepatocellular carcinomas. Submitted in Hepatology.
  2. 2.  Loutrari, Η., Magkouta, S., Papapetropoulos, A. and Roussos, C. (2011) Mastic Oil Inhibits the Metastatic Phenotype of Mouse Lung Adenocarcinoma Cells. Cancers, 3, 789-801
  3. 3.  Theodossiou, E., Loutrari, H., Stamatis, H. Roussos C, Kolisis FN. (2011), Biocatalytic synthesis and antitumor activities of novel silybin-acylated derivatives with dicatboxylic acids. N Biotechnol. 28(4):342-8
  4. 4.  Morbidelli, L., Pyriochou, A., Filippi, S., Vassiliades, Y., Roussos, C., Loutrari, H., Giannis, A., Stössel, A., Ziche, M. and Papapetropoulos, A. (2010). The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability. Am J Physiol Regul Integr Comp Physiol., 298(3):R824-32.
  5. 5.  Moulos, P. Papadodima, O., Chatziioannou, A., Loutrari, H., Roussos C and Kolisis, F.N. (2009). A transcriptomic computational analysis of mastic oil-treated Lewis lung carcinomas reveals molecular mechanisms targeting tumor cell growth and survival BMC Med Genomics, 2:68.
  6. 6.  Magkouta, S., Stathopoulos, G.T., Psallidas, I., Papapetropoulos, A., Kolisis, F.N., Roussos, C. and Loutrari, H. (2009). Protective effects of mastic oil from Pistacia lentiscus variation chia against experimental growth of Lewis Lung Carcinoma. Nutrition & Cancer, 61(5): 640-648
  7. 7.  Theodossiou, E., Katsoura, M.H., Loutrari, H., Purchartova , K., Kren, V., Kolisis, F.N. and Stamatis, H. (2009). Enzymatic preparation of acylated derivatives of silybin in organic and ionic liquids media and evaluation of their anti-tumor proliferative activity. Biocatalysis and Biotransformations, 27: 161 – 169
  8. 8.  Xanthakis, E., Magkouta, S., Loutrari, H., Stamatis, H., Roussos, C. and Kolisis, F.N. (2009). Enzymatic synthesis of perillyl alcohol derivatives and investigation of their antiproliferative activity. Biocatalysis and Biotransformation, 27: 170– 178.  
  9. 9.  Xanthakis, E., Theodossiou, E., Stamatis, H., Magkouta, S., Loutrari, H., Roussos, C. and Kolisis, F.N. (2009). Biotransformations of natural compounds: Structural and functional diversity of novel derivatives. Pure and Applied Chemistry, 82:1-16

10. Stathopoulos, G.T., Moschos, C., Loutrari, H., Kollintza, A., Psallidas, I., Karabela, S., Magkouta, S., Zhou, Z., Papiris, S.A., Roussos, C. and Kalomenidis, I. (2008). Zoledronic acid is effective against experimental malignant pleural effusion. American Journal of Respiratory and Critical Care Medicine, 178:50-59

11. Loutrari, Η., Magkouta, S., Pyriochou, A., Koika, V., Kolisis, F.N., Papapetropoulos, A. and Roussos, C. (2006). Mastic oil from Pistacia lentiscus var. chia inhibits growth and survival of human K562 leukemia cells and attenuates angiogenesis. Nutrition & Cancer. 55:86-93.

12. Mellou, F., Loutrari, H., Stamatis, H., Roussos, C. and Kolisis F.N. (2006). Enzymatic esterification of flavonoids with unsaturated fatty acids: Effect of the novel esters on Vascular Endothelial Growth Factor release from K562 cells. Process Biochemistry.41:2029-2034

13. Kotanidou A., Loutrari H., Papadomichelakis E., Glynos K., Magkou C., Armaganidis A., Papapetropoulos A., Roussos C. and Orfanos S.E. (2006). Inhaled activated protein C attenuates lung injury induced by endotoxin in mice. Vascular Pharmacology, 45: 134-140

14. Loutrari, H., Hatziapostolou, M., Skouridou, V., Papadimitriou, E., Roussos,  C., Kolisis, F.N. and Papapetropoulos, A. (2004) Perillyl alcohol is an angiogenesis inhibitor. J Pharmacol Exp Ther. 311:568-75.

15. Franqueville, Ε., Loutrari, H., Mellou, F., Stamatis, H., Friboulet,  A. and Kolisis F.N.  (2003). Reverse micelles, a system for antibody-catalysed reactions. J. Mol. Catalysis B: Enzymatic,  21: 15-17.

16. Franqueville, Ε., Stamatis, H.,  Loutrari, H, Friboulet,  A. and Kolisis F.N. (2002). Studies on the catalytic behaviour of a cholinesterase-like abzyme in an AOT microemulsion system. J. Biotechnology,  97: 177-182.

17. Loutrari, H., Kokla, A., Trakas, N. and Tzartos, S.J. (1997). Expression of human-Torpedo hybrid acetylcholine receptor (AChR) for analyzing the subunit specificity of antibodies in sera from patients with myasthenia gravis (MG). Clin. Exp. Immunol., 109: 538-546.

18. Vretou, E., Loutrari, H., Mariani,L.,  Costelidou, K., Eliades, P., Conidou, G., Karamanou S.,  Mangana, O. , Siarkou, V ., Papadopoulos, O., (1996) Diversity among abortion strains of  Chlamydia psittaci demonstrated by inclusion morphology, polypeptide profiles and monoclonal antibodies. Veterinary Microbiology 51: 275-289.

19. Loutrari, H., Kokla, A. and Tzartos, S.J. (1992). Passive transfer of experimental myasthenia gravis via antigenic modulation of acetylcholine receptor. Eur. J. Immunol, 22: 2449-2452.

20. Loutrari, H., Tzartos, S.J. and Claudio, T. (1992). Use of Torpedo‑mouse hybrid acetylcholine receptors reveals immunodominance of the a‑subunit in myasthenia gravis antisera. Eur. J. Immunol., 22: 2949-2956.

21. Tzartos, S.J., Cung, M.T., Demange, P., Loutrari, H., Mamalaki, A., Marraud, M., Papadouli, I., Sakarellos, C., and Tsikaris, V. (1992). The main immunogenic region (MIR) of the nicotinic acetylcholine receptor and the anti‑MIR antibodies. Mol. Neurobiology, 5: 1-29.

22. Tzartos, S.J., Barkas, T., Cung, M.T., Kordossi, A., Loutrari, H., Marraud, M., Papadouli, I., Sakarellos, C., Sophianos, D. and Tsikaris, V. (1991). The main immunogenic region of the acetylcholine receptor. Structure and role in myasthenia gravis. Autoimmunity, 8: 259‑270.

23. Tzartos, S.J., Loutrari, H.V., Tang, F., Kokla, A., Walgrave, S.L., Milious, R. and Conti‑Tronconi, B.M., (1990). Main immunogenic region of Torpedo electroplax and human muscle acetylcholine receptor: Localization and micro‑heterogeneity revealed by the use of synthetic peptides. J. Neurochem., 54: 51‑61.

 

 Articles to be published

 

Papadodima, O., Loutrari, H., Kolisis, F.N. and Chatziioannou, A. Global gene expression profiling and computational investigation indicates modulation of major common pathways in mastic oil-treated human K562 lymphoblastomas, A549 lung and HCT116 colon carcinomas. Manuscript in preparation